| Home | E-Submission | Sitemap | Contact Us |  
top_img
Algae > Volume 37(3); 2022 > Article
Algae 2022;37(3): 239-247. doi: https://doi.org/10.4490/algae.2022.37.9.12
Structural characterization and anti-inflammatory activity of fucoidan isolated from Ecklonia maxima stipe
Hyo-Geun Lee1, D. P. Nagahawatta1, N. M. Liyanage1, H. H. A. C. K. Jayawardhana1, Fengqi Yang1, Jun-Geon Je1, Min-Cheol Kang2, Hyun-Soo Kim3,*, You-Jin Jeon1,*
1Department of Marine Life Sciences, Jeju National University, Jeju 63243, Korea
2Research Group of Food Processing, Korea Food Research Institute, Wanju 55365, Korea
3National Marine Biodiversity Institute of Korea, Seocheon 33362, Korea
*Corresponding Author  Hyun-Soo Kim, 
Email: gustn783@mabik.re.kr
You-Jin Jeon, Tel: +82-64-754-3475, 
Email: youjin2014@gmail.com
Received: August 4, 2022;  Accepted: September 12, 2022.  Published online: September 15, 2022.
This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
ABSTRACT
Enzyme-assisted hydrolysis is frequently used as a cost-effective and efficient method to obtain functional ingredients from bioresources. This study involved the enzyme-assisted hydrolyzation and purification of fucoidan from Ecklonia maxima stipe and the investigation of its anti-inflammatory activity in lipopolysaccharide (LPS)-induced RAW 264.7 cells. Fucoidans of Viscozyme-assisted hydrolysate from E. maxima (EMSFs) harvested in Jeju, Korea. Structural and chemical characterizations were performed using fourier transform infrared spectroscopy, scanning electron microscope, and monosaccharide analysis. Among fucoidans, EMSF6 was rich in fucose and sulfate and had a similar structural character to commercial fucoidan. EMSF6 showed a strong inhibitory effect on nitric oxide generation in LPS-induced RAW 264.7 cells and significantly decreased the production of LPS-induced pro-inflammatory cytokines, including interleukin-6, interleukin-1β, and tumor necrosis factor α. The anti-inflammatory potential of EMSF6 was mediated through the downregulation of inducible nitric oxide synthase and cyclooxygenase-2 expression. Thus, fucoidans from E. maxima stipe are promising candidates for functional food products.
Key words: anti-inflammatory activity; Ecklonia maxima; fucoidan


Editorial Office
[14348] A-1716, Gwangmyeong Trade Center, 72 Iljik-ro Gwangmyeong-si. Gyeonggi-do, Korea
Tel: +82-2-899-5980  Fax: +82-2-899-5922    E-mail: editalgae@gmail.com
About |  Browse Articles |  Current Issue |  For Authors and Reviewers
Copyright © The Korean Society of Phycology.                 Developed in M2PI