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ALGAE > Volume 29(4); 2014 > Article
ALGAE 2014;29(4): 343-353. doi: https://doi.org/10.4490/algae.2014.29.4.343
Anti-inflammatory effect of polyphenol-rich extract from the red alga Callophyllis japonica in lipopolysaccharide-induced RAW 264.7 macrophages
BoMi Ryu1, Il-Whan Choi2, Zhong-Ji Qian3, Soo-Jin Heo4, Do-Hyung Kang4, Chulhong Oh4, You-Jin Jeon5, Chul Ho Jang6, Won Sun Park7, Kyong-Hwa Kang8, Jae-Young Je8, Se-Kwon Kim8, Young-Mog Kim9, Seok-Chun Ko10, GeunHyung Kim11 and Won-Kyo Jung12,*

1School of Pharmacy, The University of Queensland, Brisbane, QLD 4072, Australia
2Department of Microbiology, College of Medicine and Advanced Research Center for Multiple Myeloma, Inje University, Busan 614-735, Korea
3College of Food Science and Technology, Guangdong Ocean University, Zhanjiang 524088, China
4Global Bioresources Research Center, Korea Institute of Ocean Science and Technology, Ansan 426-744, Korea
5Department of Marine Life Sciences, Jeju National University, Jeju 690-756, Korea
6Department of Otolaryngology, Chonnam National University Medical School, Gwangju 501-746, Korea
7Department of Physiology, School of Medicine, Kangwon National University, Chuncheon 200-701, Korea
8Department of Marine-bio Convergence Science, Pukyong National University, Busan 608-737, Korea
9Department of Food Science and Technology, Pukyong National University, Busan 608-737, Korea
10Institute of Marine Biotechnology, Pukyong National University, Busan 608-737, Korea
11Department of Biomechatronic Engineering, College of Biotechnology and Bioengineering, Sungkyunkwan University, Suwon 440-746, Korea
12Department of Biomedical Engineering and Centre for Marine-Integrated Biomedical Technology (BK21 Plus), Pukyong National University, Busan 608-737, Korea
*Corresponding Author  Email: wkjung@pknu.ac.kr
Despite the extensive literature on marine algae over the past few decades, a paucity of published research and studies exists on red algae. The purpose of this study was to evaluate the potential therapeutic properties of the ethanol extract of the red alga Callophyllis japonica against lipopolysaccharide (LPS)-stimulated macrophage inflammation. The C. japonica extract (CJE) significantly inhibited the nitric oxide (NO) production and the induced dose-dependent reduction of the protein and mRNA levels of inducible nitric oxide synthase and cyclooxygenase-2. Additionally, the CJE reduced the mRNA levels of inflammatory cytokines, including tumor necrosis factor-α, interleukin (IL)-1β, and IL-6. We investigated the mechanism by which the CJE inhibits NO by examining the level of mitogen-activated protein kinases (MAPKs) activation, which is an inflammation-induced signaling pathway in macrophages. The CJE significantly suppressed the LPS-induced phosphorylation of c-Jun N-terminal kinase, extracellular signal-regulated kinase and p38 MAPK. Taken together, the results of this study demonstrate that the CJE inhibits LPS-induced inflammation by blocking the MAPK pathway in macrophages.
Key words: Callophyllis japonica; inflammation; macrophages; MAPKs

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